Hi Mitch ,
It is possible to create campaigns() using PPDS Optimizer & Heuristics with generated setup matrix. For this you have to create dummy PPMs & dummy products and assign to setup transitions.
For more details, pls go thru below link
http://help.sap.com/saphelp_em70/helpdata/en/e5/e28d6bd43911d6b2c400508b5d5211/content.htm
Hope this helps.
Regards,
Kiru